PubMed HealthSearch

PubMed · 9382397

Databases in the next millennium.

Abstract

Predicting the likelihood that large databases will become an important instrument for medical quality improvement is at least as difficult as most prognostication. This attempt at prediction starts by trying to ask the right questions: Can data serve as the agent for meaningful improvement? Is meaningful improvement possible without data? What elements are necessary and sufficient for improving the quality of medical care? It then looks for answers, starting with an unconventional excursion into the history of database use. This is followed by a recognition that the use of large databases for medical quality improvement is a true innovation, the future of which will probably be determined as much by the social and emotional forces that govern the diffusion of all innovations as by the technical strength of databases themselves. Finally, it examines some of the limitations and pitfalls that are likely to be associated with the increasing use of large databases in medicine.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F Davidoff. 1997-10-15. Databases in the next millennium.. https://doi.org/10.7326/0003-4819-127-8_part_2-199710151-00067

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Transcriptional factor mutations reveal regulatory complexities of heat shock and newly identified stress genes in Saccharomyces cerevisiae.

A computer-aided pattern search of the entire yeast genome was designed and used to identify 186 putative stress response element-regulated genes in Saccharomyces cerevisiae. Transcript levels of eight of these candidate genes were examined, and three (37%) were shown to be heat shock- and DNA damage-inducible and to require the Msn2p and Msn4p transcriptional activators for stress regulation. Significantly, several heat shock protein (HSP) genes were identified in this computer search. Using a series of single and multiple regulatory mutants, we demonstrate unexpected regulatory complexities among the HSP genes from S. cerevisiae following heat shock.

Databases, Factual

Gene therapy and medical genetics on Internet.

In this report we consider the development of the Internet, from its origins as a military invention in the times of the cold war to its present day role, together with the World Wide Web, as a means of global communication which plays a key role in medical research and particularly in medical genetics. A few of the major genetics related research projects and gene research centers are introduced and their aims are briefly discussed. Detailed information about chromosome and gene mapping, together with sequence and structure databases, can be easily and rapidly accessed through the Internet. A variety of web-sites are briefly described and then listed at the end of the report, which will serve as a useful starting point from which the interested reader can access an almost endless source of genetics related information on the Internet. Finally, some of the ethical, legal and social implications of the links between gene therapy and the Intemet are considered.

Databases, Factual