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Transcription control: repressed repeats express themselves.

A P Wolffe
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Abstract

Multi-copy transgenes are poorly expressed in plants, Drosophila and mammals; this repression is relieved by reducing copy number, leading to chromatin remodeling and transcriptional activation. Host defense mechanisms monitor repeated sequences in the genome, modulating their chromatin packaging and functional capabilities.

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AnimalsDrosophilaDrosophila ProteinsGene Expression RegulationHumansInsect ProteinsPolycomb Repressive Complex 1Repetitive Sequences, Nucleic AcidRepressor ProteinsTranscription, GeneticTransfectionTransgenesJournal ArticleReview

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A P Wolffe. 1997-12-01. Transcription control: repressed repeats express themselves.. https://doi.org/10.1016/s0960-9822(06)00408-8

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