Let's get specific: the relationship between specificity and affinity.

B E Eaton; L Gold; D A Zichi

doi:10.1016/1074-5521(95)90023-3

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Let's get specific: the relationship between specificity and affinity.

B E Eaton·L Gold·D A Zichi

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Abstract

The factors that lead to high-affinity binding are a good fit between the surfaces of the two molecules in their ground state and charge complementarity. Exactly the same factors give high specificity for a target. We argue that selection for high-affinity binding automatically leads to highly specific binding. This principle can be used to simplify screening approaches aimed at generating useful drugs.

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Animals Drug Design Humans Protein Binding Receptors, Drug Surface Properties Journal Article Review

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B E Eaton, L Gold, D A Zichi. 1995. Let's get specific: the relationship between specificity and affinity.. https://doi.org/10.1016/1074-5521(95)90023-3

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