PubMed · 9386466
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R Aldridge. 1997. From darkness with courage..... https://pubmed.ncbi.nlm.nih.gov/9386466/
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HISTORY AND CLINICAL FINDINGS: A 48-year-old patient from Pakistan was referred with scleral icterus, ascites and lower limb edema. DIAGNOSIS: The patient was suffering from post-hepatitis liver cirrhosis, CHILD stage B, with underlying chronic hepatitis B and C coinfection. TREATMENT AND COURSE: One year after diagnosis, orthotopic liver transplantation (OLT) was performed. To avoid recurrence of the hepatitis B in the transplant, the patient was given a treatment with lamivudine preoperatively. A prophylaxis with a combination of lamivudine and hepatitis B immunoglobulin peri- and postoperatively has been given for more than 5 years. CONCLUSION: The use of lamivudine and hepatitis B immunoglobulin improves transplant survival in patients who have undergone OLT on the basis of post-hepatitis liver cirrhosis secondary to chronic hepatitis B. Costs are reduced by administering the hepatitis B immunoglobulin intramuscularly and by managing the preoperative and aftercare of the patient on an outpatient basis.
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