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PubMed · 9387135

Glomerular atherosclerosis.

J F Moorhead·C Brunton·Z Varghese
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Abstract

This paper suggests a two-hit model for lipoprotein-mediated progressive renal disease, in which postsecretory modification of low-density lipoprotein may favour the transformation of mesangial cells, monocytes and macrophages to glomerular foam cells. Proteinuria and lipiduria would mediate tubulointerstitial damage. Based on this, careful treatment with lipid-lowering agents, lipopheresis and antioxidants may ameliorate the progression of glomerular and tubulointerstitial pathology.

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ArteriosclerosisHemodynamicsHumansHyperlipidemiasKidney Failure, ChronicLipoproteinsLipoproteins, LDLNephrotic SyndromeOxidation-ReductionJournal ArticleReview

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J F Moorhead, C Brunton, Z Varghese. 1997. Glomerular atherosclerosis.. https://pubmed.ncbi.nlm.nih.gov/9387135/

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