[Chemosensitivity test for human osteosarcoma cells].

C Liu; G Dai; X Zhang

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PubMed · 9387299

[Chemosensitivity test for human osteosarcoma cells].

C Liu·G Dai·X Zhang

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Abstract

In this experiment, the sensitivity of human osteosarcoma cells to various concentration gradients of HDMTX, VCR, CBP, MMC, VP16, PMB and their time-effect relationship were examined in vitro with MTT assay among 23 cases' fresh osteosarcoma (OS) tissues. It was found that OS was sensitive to MMC and PMB when the drug concentrations were equal to the calculated in vivo drug concentrations. When the concentrations were 5 times as high as those of the calculated in vivo concentrations, OS was sensitive to HDMTX, CBP, MMC and PMB. The positive rates of sensitivity were highest in 72 hours with an average of 55.1%.

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Antibiotics, Antineoplastic Bone Neoplasms Drug Screening Assays, Antitumor Epirubicin Humans Mitomycin Osteosarcoma Tumor Cells, Cultured English Abstract Journal Article Research Support, Non-U.S. Gov't

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C Liu, G Dai, X Zhang. 1996. [Chemosensitivity test for human osteosarcoma cells].. https://pubmed.ncbi.nlm.nih.gov/9387299/

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