Using multiple alignments and phylogenetic trees to detect RNA secondary structure.

B Gulko; D Haussler

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PubMed · 9390243

Using multiple alignments and phylogenetic trees to detect RNA secondary structure.

B Gulko·D Haussler

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Abstract

We describe a statistical method to determine if a pair of columns in a multiple alignment of a homologous family of RNA sequences shows evidence of being base paired. The method makes explicit use of a given phylogenetic tree for the sequences in the alignment. It is tested on a multiple alignment of 16S rRNA sequences with good results.

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Base Composition Base Sequence Computer Simulation Evolution, Molecular Models, Genetic Nucleic Acid Conformation Phylogeny Probability RNA RNA, Ribosomal, 16S Reproducibility of Results Sequence Alignment Comparative Study Journal Article

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B Gulko, D Haussler. 1996. Using multiple alignments and phylogenetic trees to detect RNA secondary structure.. https://pubmed.ncbi.nlm.nih.gov/9390243/

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