A CTD function linking transcription to splicing.

J L Corden; M Patturajan

doi:10.1016/s0968-0004(97)01125-0

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A CTD function linking transcription to splicing.

J L Corden·M Patturajan

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Abstract

Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

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Animals Humans RNA Polymerase II RNA Precursors RNA Splicing Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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J L Corden, M Patturajan. 1997. A CTD function linking transcription to splicing.. https://doi.org/10.1016/s0968-0004(97)01125-0

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