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PubMed · 94026

F cells in gynaecologic malignancy.

J Barton·M N Cauchi
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Abstract

Red cells containing Hb F (F cells) were detected by immunofluorescence using a specific antiserum. In normal persons, the number of F cells was 2.5 +/- 1.1%. A significantly increased number of F cells was found in 65% of patients with cancer of the ovary, 69% of patients with cancer of the endometrium and in 22% of patients with cancer of the cervix. Highest values were obtained in cancer of the ovary and endometrium. There was no correlation between the number of F cells and stage of disease or degree of differentiation. It is postulated that in patients with malignant disease a humoral factor is produced which interferes with normal erythropoiesis resulting in a process of dedifferentiation.

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Antibody FormationFemaleFetal HemoglobinFluorescent Antibody TechniqueGenital Neoplasms, FemaleHumansInfant, NewbornOvarian NeoplasmsUterine Cervical NeoplasmsUterine NeoplasmsJournal Article

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J Barton, M N Cauchi. 1979. F cells in gynaecologic malignancy.. https://doi.org/10.1159/000299964

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