Dendritic cell development: multiple pathways to nature's adjuvants.

K Shortman; C Caux

doi:10.1002/stem.150409

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Dendritic cell development: multiple pathways to nature's adjuvants.

K Shortman·C Caux

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Abstract

Dendritic cells are a system of bone marrow-derived antigen-presenting cells specialized for interaction with T lymphocytes and essential for initiating primary T cell immune responses. Recent investigation indicates that dendritic cells are of diverse origin, with at least two types of myeloid precursors and a lymphoid precursor implicated in their generation. Mature dendritic cell subtypes, while sharing the capacity to activate T cells, show additional functional specialization. Some dendritic cells are equipped with additional mechanisms to regulate the response of the T cells they activate, while others are able to interact with B cells and modify B cell responses.

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Animals Bone Marrow Cells Cell Differentiation Dendritic Cells Humans Langerhans Cells Models, Biological Thymus Gland Journal Article Review

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K Shortman, C Caux. 1997. Dendritic cell development: multiple pathways to nature's adjuvants.. https://doi.org/10.1002/stem.150409

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