How rolling circle plasmids control their copy number.

A Rasooly; R S Rasooly

doi:10.1016/s0966-842x(97)01143-8

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How rolling circle plasmids control their copy number.

A Rasooly·R S Rasooly

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Abstract

Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational and post-translational levels.

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DNA Helicases DNA Replication DNA-Binding Proteins Models, Biological Plasmids RNA Trans-Activators Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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A Rasooly, R S Rasooly. 1997. How rolling circle plasmids control their copy number.. https://doi.org/10.1016/s0966-842x(97)01143-8

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