The mitochondrial processing peptidase.

H P Braun; U K Schmitz

doi:10.1016/s1357-2725(97)00032-0

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PubMed · 9415998

The mitochondrial processing peptidase.

H P Braun·U K Schmitz

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Abstract

The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.

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Animals Biological Transport Dimerization Metalloendopeptidases Mitochondria Neurospora Plants Protein Sorting Signals Mitochondrial Processing Peptidase Journal Article Research Support, Non-U.S. Gov't Review

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H P Braun, U K Schmitz. The mitochondrial processing peptidase.. https://doi.org/10.1016/s1357-2725(97)00032-0

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