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Clinicopathologic differences between diploid and tetraploid complete hydatidiform moles.

C Bewtra·S Frankforter·J N Marcus
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Abstract

Complete hydatiform moles (CHM) may be are diploid or tetraploid. The proportions vary in the literature. To date, there has not been a systematic characterization of these two types. This study is a retrospective investigation of clinicopathologic differences between diploid and tetraploid CHMs. Thirteen formalin-fixed, paraffin-embedded CHMs were analyzed for DNA content by flow cytometry (FC). Using standard flow cytometric definitions, histograms were classified as FC-diploid or FC-tetraploid (4N peak > or = 15% of 2N peak and cell cycle events to 8N) and compared with respect to selected clinical and pathologic features. Eight CHMs (61%) met the criteria of tetraploidy by flow cytometry, although all five FC-diploid cases harbored minor (< 15%) tetraploid subpopulations. Patients with tetraploid moles were older (mean age 32.8 years vs. 19.6 years, p < 0.005), presented at lower preevacuation gestational ages (12.7 weeks vs. 15.4 weeks, p < 0.05), had higher mean serum beta-HCG levels (2.82 x 10(5) i.u. vs. 0.99 x 10(5) i.u., p = 0.07), and higher DNA S-phase fractions (17.9% vs. 7.0%, p = 0.002). No significant differences were found in other histological features. No moles recurred. In this small sample of CHMs, tetraploidy was common. Compared with the FC-diploid CHMs, FC-tetraploid CHMs occurred in older patients with lower gestational age, higher serum beta-HCG levels, and higher DNA S-phase fraction by flow cytometry.

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Age FactorsChorionic Gonadotropin, beta Subunit, HumanDiploidyFemaleFlow CytometryGestational AgeHumansHydatidiform MoleMitotic IndexPolyploidyPregnancyRetrospective StudiesUterine NeoplasmsJournal ArticleResearch Support, Non-U.S. Gov't

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C Bewtra, S Frankforter, J N Marcus. 1997. Clinicopathologic differences between diploid and tetraploid complete hydatidiform moles.. https://doi.org/10.1097/00004347-199707000-00008

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