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PubMed · 9427849

Adrenal function predicts demoralization after losses.

S Jacobs·M Bruce·K Kim
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Abstract

Stressful experiences can cause disturbances in the hypothalamic-pituitary-adrenocortical axis and the sympathetic-adrenomedullary system. The authors hypothesized that assessments of adrenal function made in the circumstances of stressful losses would predict outcome 1 or 2 years later. The authors collected 24-hour urinary free cortisol, serum cortisol, and 24-hour urinary catecholamines 2 months after intake and used these measures as predictors of depression, anxiety, hopelessness/helplessness, unresolved grief, self-rated health, and help-seeking behavior on follow-up at 13 and 25 months. Adrenal function in the circumstances of a loss predicted only demoralization scores (hopelessness/helplessness) on follow-up.

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Adrenal InsufficiencyAgedCatecholaminesDepressive DisorderFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemLife Change EventsLongitudinal StudiesMaleMiddle AgedPituitary-Adrenal SystemJournal Article

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S Jacobs, M Bruce, K Kim. Adrenal function predicts demoralization after losses.. https://doi.org/10.1016/s0033-3182(97)71397-5

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PubMed2007

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