Chain termination codons and polymerase-induced frameshift mutations.

J L Jestin; A Kempf

doi:10.1016/s0014-5793(97)01422-1

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Chain termination codons and polymerase-induced frameshift mutations.

J L Jestin·A Kempf

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Abstract

The consensus sequence for single-base deletions in non-reiterated runs during in vitro DNA-dependent DNA polymerisation is refined using data available in the literature. This leads to the observation that chain termination codons are hotspots for single-base deletions. The evolutionary implications are discussed in two models which differ in whether polymerases evolved while the genetic code emerged or after the genetic code was fixed. A possible answer to the question 'Why are stop codons just what they are?' is suggested.

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Animals Codon, Terminator DNA-Directed DNA Polymerase Frameshift Mutation Humans Journal Article Research Support, Non-U.S. Gov't Review

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J L Jestin, A Kempf. 1997-12-15. Chain termination codons and polymerase-induced frameshift mutations.. https://doi.org/10.1016/s0014-5793(97)01422-1

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