Cis-unsaturated fatty acids and platelet function.

M Mutanen

doi:10.1016/s0952-3278(97)90419-1

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Cis-unsaturated fatty acids and platelet function.

M Mutanen

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Abstract

The main method to study platelet function in dietary studies has been the platelet aggregation test in vitro. Even though it is well established that dietary cis-unsaturated fatty acids (FAs) modify platelet aggregation some uncertainty still exists how to interpret the in vitro results in the context of a situation in vivo. The other ways to look at platelet activation are measurements of thromboxane metabolites in urine or the concentration of beta-thromboglobulin (betaTG) released from alpha-granules. Dietary fish oil or long-chain n-3 FAs lower the high basal excretion rate of thromboxane, while only a modest effect is noticed at a low basal excretion rate. Results on the effects of other cis-unsaturated FAs on urinary TXB2 metabolites are almost totally lacking. Furthermore, platelet betaTG release in vivo does not seem to be affected by changes in dietary FAs. The regulatory function of dietary FAs in platelets is extremely complex, and clearly more should be understood about the association between dietary FAs and platelet membrane FAs in connection with platelet responses to physiological stimuli and subsequent signal transduction inside the platelets.

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Arachidonic Acids Blood Platelets Dietary Fats, Unsaturated Fats, Unsaturated Fatty Acids Humans Platelet Activation Platelet Aggregation Signal Transduction Journal Article Review

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M Mutanen. 1997. Cis-unsaturated fatty acids and platelet function.. https://doi.org/10.1016/s0952-3278(97)90419-1

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