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A comprehensive analysis of complex traits in problem 2A.

S H Juo·T H Beaty·D L Duffy·N E Maestri·V L Prenger·J Zeiger·H H Lei·J Coresh
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Abstract

We used descriptive analysis to investigate the relationship between affection status and five quantitative traits (Q1-Q5) in Problem 2A and results suggested the five quantitative traits fall into two groups. The first group comprised three strongly correlated traits, Q1-Q3, which underlie affection status, and the second group comprised Q4 and Q5, which are not directly related to affection status. Segregation and linkage analyses of traits Q1-Q3 and affection status from the first replicate detected one of the major loci for Q1 (MG1) linked to marker 14 on chromosome 5 (D5G14). Because our segregation analysis failed to show evidence of a major locus effect on Q2, and we overlooked the interaction between MG3 and sex, we did not detect either MG2 or MG3. Using Haseman-Elston sib-pair analysis [Haseman and Elston, 1972], we also examined the statistical power of Q1 and type I error rate (using the environmental factor as an index), for the remaining 199 replicates in the context of a genome screen.

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Chromosome MappingEnvironmentFemaleGenetic LinkageGenetic MarkersGenetic Predisposition to DiseaseGenome, HumanHumansLinear ModelsLod ScoreMaleMatched-Pair AnalysisModels, StatisticalNuclear FamilyPredictive Value of TestsQuantitative Trait, HeritableClinical TrialControlled Clinical TrialJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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S H Juo, T H Beaty, D L Duffy, N E Maestri, V L Prenger, J Zeiger, H H Lei, J Coresh. 1997. A comprehensive analysis of complex traits in problem 2A.. https://doi.org/10.1002/(sici)1098-2272(1997)14%3A6%3C815%3A%3Aaid-gepi42%3E3.0.co%3B2-q

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