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Comparison of evidence for linkage from different analytic methods.

S B Bull·D Pinnaduwage·J Shin·F Xie·D Tritchler
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Abstract

In a randomly chosen replicate of extended pedigrees from GAW10, we conducted robust multipoint genome scans for linkage using a dense marker map. For analysis of the quantitative traits, we selected sibships from the pedigrees, and for analysis of disease status, small families of affected relatives were selected. Lod-score likelihood analyses were conducted in the full pedigrees and in the affected relative families for selected regions. We located a flanking marker for MG1 on chromosome 5, and identified marker regions including MG2, MG4, and MG5 on chromosomes 8 and 9. The analytic methods were consistent for the major gene with a strong effect; false positive errors on chromosomes 1 and 10 could have been eliminated by requiring evidence from more than one method.

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FemaleGenetic LinkageGenetic MarkersGenetic TestingGenome, HumanHumansLikelihood FunctionsLod ScoreMaleMatched-Pair AnalysisNuclear FamilyPedigreeQuantitative Trait, HeritableRegression AnalysisClinical TrialComparative StudyJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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S B Bull, D Pinnaduwage, J Shin, F Xie, D Tritchler. 1997. Comparison of evidence for linkage from different analytic methods.. https://doi.org/10.1002/(sici)1098-2272(1997)14%3A6%3C965%3A%3Aaid-gepi67%3E3.0.co%3B2-j

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