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Detecting gene-environment interactions using a case-control design.

A M Goldstein·R T Falk·J F Korczak·J H Lubin
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Abstract

We assessed the sample size required for detecting gene-environment (G x E) interactions in a case-control study of complex diseases. The results suggest that large numbers of cases and controls will be required to detect G x E interaction for some odds ratio and exposure frequency combinations. These and other results suggest that alternative study designs may be needed to detect G x E interaction particularly with rare genes or uncommon environmental exposures.

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Case-Control StudiesEnvironmentGene FrequencyGenetic Diseases, InbornHumansOdds RatioRisk FactorsSample SizeJournal Article

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A M Goldstein, R T Falk, J F Korczak, J H Lubin. 1997. Detecting gene-environment interactions using a case-control design.. https://doi.org/10.1002/(sici)1098-2272(1997)14%3A6%3C1085%3A%3Aaid-gepi87%3E3.0.co%3B2-d

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