T-cell receptor structure and TCR complexes.

I A Wilson; K C Garcia

doi:10.1016/s0959-440x(97)80156-x

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PubMed · 9434905

T-cell receptor structure and TCR complexes.

I A Wilson·K C Garcia

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Abstract

The first crystal structures of intact T-cell receptors (TCRs) and their complexes with MHC peptide antigens (pMHC) were reported during the past year, along with those of a single-chain TCR Fv fragment and a beta-chain complexed with two different bacterial superantigens. These structures have shown the similarities and differences in the architecture of the antigen-binding regions of TCRs and antibodies, and how the TCR interacts with pMHC ligands as well as with superantigens.

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Animals Antigens, Bacterial Binding Sites Crystallography, X-Ray Histocompatibility Antigens Humans Models, Molecular Protein Structure, Tertiary Receptors, Antigen, T-Cell Superantigens Journal Article Research Support, U.S. Gov't, P.H.S.Review

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I A Wilson, K C Garcia. 1997. T-cell receptor structure and TCR complexes.. https://doi.org/10.1016/s0959-440x(97)80156-x

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