Endothelial cell monolayers as a tool for studying microvascular pathophysiology.

P R Kvietys; D N Granger

doi:10.1152/ajpgi.1997.273.6.g1189

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Endothelial cell monolayers as a tool for studying microvascular pathophysiology.

P R Kvietys·D N Granger

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Abstract

Endothelial cells contribute to a variety of biological responses that facilitate organ function. This critical role of the endothelial cell has resulted in the development of different in vitro models that utilize monolayers of cultured cells to simulate conditions that exist in the intact animal. This review focuses on endothelial cell monolayers as a model system for research on certain pathophysiological conditions affecting the gastrointestinal tract. The advantages and limitations of endothelial cell monolayers are addressed, along with evolving technologies and strategies that hold promise for extending the utility of this in vitro model for studies of gastrointestinal function and disease.

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Animals Anti-Inflammatory Agents, Non-Steroidal Cell Adhesion Molecules Cells, Cultured Endothelium, Vascular Humans Inflammation Intestinal Mucosa Microcirculation Models, Cardiovascular Reperfusion Injury Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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P R Kvietys, D N Granger. 1997. Endothelial cell monolayers as a tool for studying microvascular pathophysiology.. https://doi.org/10.1152/ajpgi.1997.273.6.g1189

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