Combinatorial approaches to gene recognition.

M A Roytberg; T V Astakhova; M S Gelfand

doi:10.1016/s0097-8485(96)00034-4

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Combinatorial approaches to gene recognition.

M A Roytberg·T V Astakhova·M S Gelfand

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Abstract

Recognition of genes via exon assembly approaches leads naturally to the use of dynamic programming. We consider the general graph-theoretical formulation of the exon assembly problem and analyze in detail some specific variants: multicriterial optimization in the case of non-linear gene-scoring functions; context-dependent schemes for scoring exons and related procedures for exon filtering; and highly specific recognition of arbitrary gene segments, oligonucleotide probes and polymerase chain reaction (PCR) primers.

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Base Sequence DNA DNA Primers Exons Genetic Techniques Mathematics Models, Genetic Molecular Sequence Data Oligonucleotide Probes Polymerase Chain Reaction Reading Frames Software Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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M A Roytberg, T V Astakhova, M S Gelfand. 1997. Combinatorial approaches to gene recognition.. https://doi.org/10.1016/s0097-8485(96)00034-4

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