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PubMed · 9441820

A circular code in the protein coding genes of mitochondria.

D G Arquès·C J Michel
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Abstract

A new maximal circular code X0(MIT) with two permutated maximal circular codes X1(MIT) and X2(MIT) is identified in the protein coding genes of mitochondria. The three subsets of 20 trinucleotides X0(MIT)={ACA, ACC, ATA, ATC, CTA, CTC, GAA, GAC, GAT, GCA, GCC, GCT, GGA, GGC, GGT, GTA, GTC, GTT, TTA, TTC}, X1(MIT) and X2(MIT) are in frame 0 (reading frame), 1 and 2 respectively. X1(MIT) and X2(MIT) are deduced by one and two circular permutations of X0(MIT) respectively. The code X0(MIT) has four important properties: a length of the minimal window to automatically retrieve frame 0 which is equal to five nucleotides; an occurrence probability equal to 6.3 x 10(-5); a low frequency (12% in average) of misplaced trinucleotides in the shifted frames; and an occurrence of four types of nucleotides in the first and second trinucleotide sites but no nucleotide G in the third trinucleotide site. Several biological consequences are presented in the Discussion.

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Amino AcidsAnimalsBase SequenceCodonDNA, MitochondrialEukaryotic CellsMitochondriaMolecular Sequence DataProkaryotic CellsProteinsReading FramesJournal Article

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D G Arquès, C J Michel. 1997-12-07. A circular code in the protein coding genes of mitochondria.. https://doi.org/10.1006/jtbi.1997.0513

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