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Rate dependent drug effects: possible state dependency.

C Ksir
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Abstract

Of 6 rats given extensive experience responding on a fixed-interval reinforcement schedule after injections of 1 mg/kg d-amphetamine, 3 showed significant rate dependent changes in responding when presession saline was substituted for d-amphetamine. Low rates were increased and high rates decreased by the change from d-amphetamine to saline, a result commonly found when d-amphetamine is first introduced. This indicates that rate dependent changes in fixed-interval responding may be state dependent phenomena.

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AnimalsConditioning, ClassicalDextroamphetamineHumansMaleRatsReinforcement ScheduleSubstance-Related DisordersTime FactorsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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C Ksir. 1976. Rate dependent drug effects: possible state dependency.. https://doi.org/10.1016/0091-3057(76)90009-5

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