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PubMed · 944933

A dose-response comparison between methadone and morphine self-administration.

T E Werner·S G Smith·W M Davis
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Abstract

Rats were allowed to self-administer a solution of 0.9% saline, or 0.01, 0.03, 0.1 or 0.3 mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine sulfate. The results showed that number of infusions taken was an inverse function of unit dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The data also indicated that more morphine than methadone was self-administered.

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AnimalsConditioning, OperantDose-Response Relationship, DrugHumansMaleMethadoneMorphineMorphine DependenceRatsComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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T E Werner, S G Smith, W M Davis. 1976-05-28. A dose-response comparison between methadone and morphine self-administration.. https://doi.org/10.1007/bf00735825

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