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PubMed · 945170

Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.

B J Sahakian·T W Robbins·S D Iversen
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Abstract

Socially reared and isolation-reared rats treated chronically since weaning with alpha-flupenthixol showed elevated levels of spontaneous locomotor activity compared with control treated rats. However, chronic apomorphine treatment had no effect on spontaneous locomotor activity. Chronic alpha-flupenthixol treatment enhanced stereotyped behaviour after 1.5 mg/kg d-amphetamine or 0.5 mg/kg apomorphine in the socially reared condition. 'Spontaneous stereotypies' were also observed in the chronic alpha-flupenthixol-treated animals. Chronic apomorphine treatment did not affect stereotyped responding. The results are discussed in terms of 'behavioural supersensitivity'.

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AnimalsApomorphineBody WeightDextroamphetamineFemaleFlupenthixolHumansMotor ActivityRatsSocial EnvironmentSocial IsolationStereotyped BehaviorStimulation, ChemicalThioxanthenesJournal Article

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BibTeXRIS

B J Sahakian, T W Robbins, S D Iversen. 1976. Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.. https://doi.org/10.1016/0014-2999(76)90019-4

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