[Cerebral amyloidosis].

Y Grignon; M A Colle; J J Hauw

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PubMed · 9453205

[Cerebral amyloidosis].

Y Grignon·M A Colle·J J Hauw

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Abstract

Cerebral amyloidoses affects only the central nervous system, with rare exceptions. Most of them are related to A beta deposits. They usually occur in the absence of genetic defect in the precursor of A beta. The prevalence and density of A beta deposits increase during the aging process, and in Alzheimer's disease. This A beta amyloidosis has never been transmitted. In contrast, PrPres occurs as a sporadic or genetic event, and induces transmissible amyloidoses (Creutzfeldt-Jakob's disease and other disorders related to non conventional agents). PrPres may be the infectious agent itself (prion hypothesis). Other proteins are rarely responsible for cerebral amyloidoses. The fascinating hypothesis that a common mechanism would be acting in all cerebral amyloidoses has not yet been confirmed.

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Amyloid Neuropathies Amyloid beta-Peptides Cerebral Amyloid Angiopathy Humans Prions English Abstract Journal Article Review

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Y Grignon, M A Colle, J J Hauw. 1997-10-15. [Cerebral amyloidosis].. https://pubmed.ncbi.nlm.nih.gov/9453205/

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