Rational interleukin-2 therapy.

K A Smith

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PubMed · 9457409

Rational interleukin-2 therapy.

K A Smith

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Abstract

The administration of cytokines that augment the function of the immune system can be accomplished safely and without toxicity, provided a rational approach is used. Such a therapeutic method should be based upon the principles of pharmacology and the structure-activity relationships of the cytokine-receptor interaction. Thus, the therapeutic index should be determined, and the goal should be to augment the function of the immune system in a variety of clinical situations, not necessarily focused on eradicating a particular disease process such as metastatic cancer that may or may not be influenced by the immune system.

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HIV Infections History, 20th Century Humans Immunotherapy Interleukin-2 Neoplasms Receptors, Interleukin-2 Structure-Activity Relationship Historical Article Journal Article Research Support, U.S. Gov't, P.H.S.

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K A Smith. 1997. Rational interleukin-2 therapy.. https://pubmed.ncbi.nlm.nih.gov/9457409/

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