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Decrease in peripheral type 1 over type 2 T cell cytokine production in patients with rheumatoid arthritis correlates with an increase in severity of disease.

J A van Roon·C M Verhoef·J L van Roy·F H Gmelig-Meyling·O Huber-Bruning·F P Lafeber·J W Bijlsma
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Abstract

OBJECTIVES: To compare peripheral type 1 (T1) and type 2 (T2) T cell activities in rheumatoid arthritis (RA) patients with that found for osteoarthritic (OA) patients and healthy controls and to correlate peripheral T1/T2 cell activity in RA with parameters of the disease. METHODS: Peripheral blood mononuclear cells were isolated from patients with RA (n = 66), OA (n = 19), and healthy controls (n = 15). Primary T cell activity in these mononuclear cells was enhanced by means of anti-CD3/anti-CD28, which mimicks stimulation of T cells by activation of the T cell receptor and a major co-stimulatory signal. Interferon gamma (IFN gamma) production and interleukin 4 (IL4) production in the three groups were quantified as measures of T1 and T2 cell activity, respectively, and compared. Serum tumour necrosis factor alpha (TNF alpha), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and joint destruction assessed radiographically of RA patients were determined as parameters of disease activity and correlated with T1/T2 cell activity. RESULTS: Peripheral T cells from RA patients produced significantly less IFN gamma and more IL4 than T cells from both age and sex matched OA patients and healthy controls. Moreover, in RA patients both a decrease in IFN gamma and an increase in IL4 production correlated with an increase in serum TNF alpha, ESR, CRP, and joint destruction. CONCLUSIONS: These results suggest a role for differential T cell activity in RA. In view of the intra-articular T1 cell predominance the results might be explained by selective T1 cell migration into the joint or peripheral suppression of T1 cell activity.

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AgedAged, 80 and overArthritis, RheumatoidArthrographyBlood SedimentationC-Reactive ProteinCytokinesFemaleHumansInterferon-gammaInterleukin-4Lymphocyte ActivationMaleMiddle AgedOsteoarthritisRegression AnalysisStatistics, NonparametricTh1 CellsTh2 CellsTumor Necrosis Factor-alphaJournal ArticleResearch Support, Non-U.S. Gov't

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J A van Roon, C M Verhoef, J L van Roy, F H Gmelig-Meyling, O Huber-Bruning, F P Lafeber, J W Bijlsma. 1997. Decrease in peripheral type 1 over type 2 T cell cytokine production in patients with rheumatoid arthritis correlates with an increase in severity of disease.. https://doi.org/10.1136/ard.56.11.656

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