Stereoselection in designed three-helix bundle metalloproteins.

M A Case; M R Ghadiri; M W Mutz; G L McLendon

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PubMed · 9470207

Stereoselection in designed three-helix bundle metalloproteins.

M A Case·M R Ghadiri·M W Mutz·G L McLendon

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Abstract

The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems.

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Circular Dichroism Entropy Iron Magnetic Resonance Spectroscopy Metalloproteins Peptides Protein Conformation Ruthenium Stereoisomerism Journal Article

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M A Case, M R Ghadiri, M W Mutz, G L McLendon. 1998. Stereoselection in designed three-helix bundle metalloproteins.. https://pubmed.ncbi.nlm.nih.gov/9470207/

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