Are changes in integrin affinity and conformation overemphasized?

G Bazzoni; M E Hemler

doi:10.1016/s0968-0004(97)01141-9

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Are changes in integrin affinity and conformation overemphasized?

G Bazzoni·M E Hemler

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Abstract

The activation of integrin-type adhesion receptors might result in the increased affinity of the receptor for ligand. In addition, the activated receptor might display new epitopes, which are increasingly monitored in clinical settings. Here, we highlight examples of integrin 'activation' that is not accompanied by enhanced ligand binding. Also, we emphasize that the dominant integrin conformational changes occur not with 'activation', but after integrins have already bound ligand.

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Animals Cell Adhesion Humans Integrins Ligands Models, Biological Protein Conformation Journal Article Review

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G Bazzoni, M E Hemler. 1998. Are changes in integrin affinity and conformation overemphasized?. https://doi.org/10.1016/s0968-0004(97)01141-9

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