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PubMed · 9487732

Inhibiting virus-capsid assembly by altering the polymerisation pathway.

P E Prevelige
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Abstract

Virus capsids assemble through the repeated interaction of well-defined protein subunits in a highly specific process. Basic research into the mechanism of protein polymerisation and virus assembly suggest that inhibition of the protein-protein interactions necessary for assembly is a valid therapeutic strategy. Computer models of virus-capsid assembly have located vulnerable stages in assembly, and small-molecule inhibitors of virus assembly have been identified. The challenge will be identifying agents that block assembly with the required specificity.

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CapsidComputer SimulationPolymersThermodynamicsVirus AssemblyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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P E Prevelige. 1998. Inhibiting virus-capsid assembly by altering the polymerisation pathway.. https://doi.org/10.1016/s0167-7799(97)01154-2

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