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PubMed · 9492829

[Correlation between pyrimidine nucleoside phosphorylase (PyNPase)/thymidine phosphorylase/platelet-derived endothelial cell growth factor and histological prognostic factor, and influence of 5'-deoxy-5-fluorouridine (5'-DFUR) administration on PyNPase activities and serum immunosuppressive acidic protein levels. A study group of oral anti-cancer drugs in Seiban/Tajima area].

B Satoh·M Ohtoshi·Y Ishida·K Hen-mi·I Kaneko·M Soda·J Sugihara·F Shibagaki·N Iwai·T Nakamura·T Yamasaki·S Matsumoto
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Abstract

PURPOSE: Among the pyrimidine nucleoside phosphorylases (PyNPase), thymidine phosphorylase (dThdPase) exists mainly in human tumor tissues, and is an enzyme which converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil. Recently, it was reported that dThdPase was identical to platelet-derived endothelial cell growth factor which was an antiogenetic factor, therefore. We think dThdPase may be a prognostic factor. METHODS: We investigated the possible correlation between PyNPase activities in tumor tissues and prognostic factors of histological findings, and examined influences of preoperative oral 5'-DFUR administration at a dose of 1,200 mg/body for 7 days on PyNPase activities and serum immunosuppressive acidic protein levels in patients with gastric cancer. RESULTS: Higher levels of PyNPase activities were especially observed in patients with v+ (p = 0.0161). PyNPase activities (p = 0.1668) and IAP (p = 0.0830) levels showed a decrease by 5'-DFUR administration. CONCLUSION: This study suggests that we must investigate in detail the possibility of PyNPase being prognostic factor, and 5'-DFUR administration may improve the prognosis of patients with gastric cancer.

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Antineoplastic AgentsDrug Administration ScheduleFemaleFloxuridineHumansMaleMiddle AgedNeoplasm ProteinsPentosyltransferasesPrognosisPyrimidine PhosphorylasesStomach NeoplasmsThymidine PhosphorylaseClinical TrialEnglish AbstractJournal ArticleMulticenter StudyRandomized Controlled Trial

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B Satoh, M Ohtoshi, Y Ishida, K Hen-mi, I Kaneko, M Soda, J Sugihara, F Shibagaki, N Iwai, T Nakamura, T Yamasaki, S Matsumoto. 1998. [Correlation between pyrimidine nucleoside phosphorylase (PyNPase)/thymidine phosphorylase/platelet-derived endothelial cell growth factor and histological prognostic factor, and influence of 5'-deoxy-5-fluorouridine (5'-DFUR) administration on PyNPase activities and serum immunosuppressive acidic protein levels. A study group of oral anti-cancer drugs in Seiban/Tajima area].. https://pubmed.ncbi.nlm.nih.gov/9492829/

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