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PubMed · 9501974

Splicing: HACking into the unfolded-protein response.

C E Shamu
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Abstract

Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase.

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Basic-Leucine Zipper Transcription FactorsFungal ProteinsProtein BiosynthesisProtein FoldingRNA SplicingRNA, MessengerRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

C E Shamu. 1998-02-12. Splicing: HACking into the unfolded-protein response.. https://doi.org/10.1016/s0960-9822(98)70986-8

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