[Gene engineering studies on sleep].

Y Urade

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PubMed · 9503856

[Gene engineering studies on sleep].

Y Urade

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Abstract

Recent advancements in molecular engineering techniques have enabled us to study sleep of animals lacking or overproducing any protein molecule we are interested in. Abnormalities in sleep have already been observe in knockout mice lacking the gene for prion protein, 55 kD-receptor of tumor necrosis factor, etc. We also started a project to examine the effect of the loss or the overproduction of prostaglandin D synthase in sleep. The enzyme is responsible for biosynthesis of prostaglandin D2, the most potent endogenous substance to promote sleep reported so far. We generated both knockout and transgenic mice of prostaglandin D synthase. We are currently analysing the sleep of these mutant mice.

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Animals Antigens, CD Humans Intramolecular Oxidoreductases Lipocalins Mice Mice, Knockout Mice, Transgenic Mutation Prions Prostaglandin D2 Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Type I Sleep Wake Disorders English Abstract Journal Article Review

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Y Urade. 1998. [Gene engineering studies on sleep].. https://pubmed.ncbi.nlm.nih.gov/9503856/

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