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PubMed · 9505877

Mid-life crisis for M cells.

R L Owen
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Abstract

The epithelium that lines the gut is impermeable to macromolecules and microorganisms, except in Peyer's patches (PP), where the lymphoid follicle-associated epithelium (FAE) contains M cells that transport antigens and microorganisms. A cultured system that reproduces the main characteristics of FAE and M cells was established by cultivation of PP lymphocytes with the differentiated human intestinal cell line Caco-2. Lymphocytes settled into the epithelial monolayer, inducing reorganization of the brush border and a temperature-dependent transport of particles and Vibrio cholerae. This model system could prove useful for intestinal physiology, vaccine research, and drug delivery studies.

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Caco-2 CellsCell DifferentiationCoculture TechniquesEpithelial CellsHumansLymphocytesModels, BiologicalPeyer's PatchesJournal Article

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R L Owen. 1998. Mid-life crisis for M cells.. https://doi.org/10.1136/gut.42.1.11

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