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Reducing noise damage by using a mid-frequency sound conditioning stimulus.

B Canlon·A Fransson
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Abstract

Sound conditioning guinea pigs to a 6.3 kHz tone at 78 dB SPL for either 13 or 24 days provides significant physiological (auditory brain stem responses, ABR; and distortion product otoacoustic emissions, DPOAE) and morphological (cochleograms) protection against a subsequent traumatic exposure (6.3 kHz, 100 dB SPL for 24 h) delivered 2 h after sound conditioning. Threshold shifts (ABR, DPOAE) were significantly reduced and the degree of hair cell loss was minimal. When a 1 week pause was given between the end of the sound conditioning and the traumatic exposure, protection was still observed, but to a lesser degree. These findings demonstrate that mid-frequency sound conditioning protects against noise trauma and that the protective effect is maintained for at least 1 week.

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Acoustic StimulationAnimalsAuditory PathwaysConditioning, PsychologicalEvoked Potentials, Auditory, Brain StemGuinea PigsHair Cells, AuditoryHearing Loss, Noise-InducedJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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B Canlon, A Fransson. 1998-01-26. Reducing noise damage by using a mid-frequency sound conditioning stimulus.. https://doi.org/10.1097/00001756-199801260-00017

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