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PubMed · 9519282

Behavioral sensitization to amphetamine is not accompanied by a decrease in the number of c-Fos containing cells in the striatum.

S M Turgeon·J E Blum·E A Auerbach
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Abstract

The expression of c-Fos-like immunoreactivity (FLI) and chronic Fos-related antigen-like immunoreactivity (FRALI) accompanying behavioral sensitization to amphetamine was assessed in male rat striatum. Animals were treated for four days with amphetamine (A; 5 mg/kg) or vehicle (V) and challenged with A or V on the fifth day. The number of FLI-positive cells in the striatum was enhanced in V-A and A-A groups as compared to control (V-V), while the number of FRALI-positive cells in the striatum was enhanced in the A-V and A-A groups as compared to control. These results suggest that the absence of a decrease in the number of striatal FLI-positive cells accompanying chronic amphetamine treatment is not due to antibody cross-reactivity with chronic FRAs, and that behavioral sensitization to amphetamine is not accompanied by a change in the number of striatal cells expressing c-Fos.

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AmphetamineAnimalsBehavior, AnimalCell CountCentral Nervous System StimulantsCorpus StriatumMaleNeuronsProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyJournal Article

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S M Turgeon, J E Blum, E A Auerbach. 1998-01-26. Behavioral sensitization to amphetamine is not accompanied by a decrease in the number of c-Fos containing cells in the striatum.. https://doi.org/10.1016/s0006-8993(97)01376-0

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