Pathways for protein folding: is a new view needed?

V S Pande; Grosberg AYu; T Tanaka; D S Rokhsar

doi:10.1016/s0959-440x(98)80012-2

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Pathways for protein folding: is a new view needed?

V S Pande·Grosberg AYu·T Tanaka·D S Rokhsar

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Abstract

Theoretical studies using simplified models of proteins have shed light on the general heteropolymeric aspects of the folding problem. Recent work has emphasized the statistical aspects of folding pathways. In particular, progress has been made in characterizing the ensemble of transition state conformations and elucidating the role of intermediates. These advances suggest a reconciliation between the new ensemble approaches and the classical view of a folding pathway.

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Computer Simulation Protein Conformation Protein Folding Proteins Thermodynamics Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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V S Pande, Grosberg AYu, T Tanaka, D S Rokhsar. 1998. Pathways for protein folding: is a new view needed?. https://doi.org/10.1016/s0959-440x(98)80012-2

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