Quantitative structure-activity relationship study of some 7-substituted theophyllines.

L Türker; H Akgün; A Balkan

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PubMed · 9522029

Quantitative structure-activity relationship study of some 7-substituted theophyllines.

L Türker·H Akgün·A Balkan

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Abstract

Some novel 7-substituted theophylline derivatives have been investigated for quantitative structure-activity relationship (QSAR). For this purpose, their bronchodilatory activities (in vitro), which were examined by the inhibition of acetylcholine induced contraction in tracheae isolated from guinea pigs, have been correlated with various quantum chemical and physicochemical parameters.

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Acetylcholine Animals Bronchodilator Agents Chemical Phenomena Chemistry, Physical Guinea Pigs In Vitro Techniques Male Muscle, Smooth Structure-Activity Relationship Theophylline Journal Article

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L Türker, H Akgün, A Balkan. 1998. Quantitative structure-activity relationship study of some 7-substituted theophyllines.. https://pubmed.ncbi.nlm.nih.gov/9522029/

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