PubMed · 9522643
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
T Gürke. 1998-01-21. [Elevated alkaline phosphatase].. https://pubmed.ncbi.nlm.nih.gov/9522643/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
A phase II programme was carried out in both Europe and North America to evaluate the activity of topotecan administered as a 21-day continuous intravenous infusion to patients with recurrent ovarian cancer. The European results are reported here. Patients who had failed first line therapy with a platinum-based regimen received topotecan 0.4 mg/m(2)/day, as a 21-day infusion every 28 days. Patients were only permitted one prior regimen. 35 patients were enrolled and evaluable for response. 3 patients (8.6%) had a partial response to treatment (95% CI 1.8%, 23.1%) with a median time to response of 8.1 weeks and a median duration of response of 17.6 weeks. Response was also evaluated by CA125 and was also found to be 8%. For all 35 patients, median time to progression was 16.1 weeks and median survival was 43.6 weeks. The principal toxicity was myelosuppression although grade 4 neutropenia occurred in only 8.8% of patients (2.1% of courses) and infectious complications were relatively infrequent. Non-haematological toxicity was generally mild and mainly consisted of gastrointestinal events, alopecia and fatigue. A prolonged infusion of topotecan was well tolerated with a low incidence of severe neutropenia. Responses were seen in both North American and European patients. Response rates varied between the 2 studies possibly due to differences in patient demographics.
Explore the source record for details and available documents.
OBJECTIVE: To estimate the prevalence of medically unexplained symptoms in patients who most frequently attend outpatient services. DESIGN: Retrospective cohort study over three years with review of case notes. SETTING: Secondary care services in the South Thames (West) NHS region. PARTICIPANTS: Outpatient attenders with new appointments in 1993. MAIN OUTCOME MEASURES: Number of outpatient appointments, and number of consultation episodes for medically unexplained conditions. RESULTS: Medical records of 361 of 400 sampled frequent attenders were examined, and 971 consultation episodes were recorded. Ninety seven (27%) had one or more consultation episodes in which the condition was medically unexplained; 208 (21%) of the 971 consultation episodes were medically unexplained. Abdominal pain, chest pain, headache, and back pain were commonly found to be medically unexplained. CONCLUSIONS: Medically unexplained symptoms present in most hospital specialties and account for a considerable proportion of consultations by frequent attenders in secondary care.