TNF receptors--how they function and interact.

J Bigda; H Holtmann

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PubMed · 9522999

TNF receptors--how they function and interact.

J Bigda·H Holtmann

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Abstract

Tumor necrosis factor (TNF) is a pleiotropic cytokine regulating various immune and inflammatory reactions. It induces cellular responses upon binding to specific cell surface receptors of two distinct molecular species--p55 and p75 TNF receptors (TNF-Rs). Cloning of the respective cDNAs and obtaining the receptor-specific molecular tools such a agonistic and blocking monoclonal antibodies, TNF muteins with exclusive ability to bind to only one receptor type, as well as generation of TNF-R mutants by site-directed mutagenesis enabled researchers to answer key questions of the biology of initial steps in the cascade of TNF signal transduction. The presented mini-review describes the mode of function of the two receptors and discusses the possible ways of interaction between them.

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Animals Humans Receptors, Tumor Necrosis Factor Signal Transduction Journal Article Research Support, Non-U.S. Gov't Review

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J Bigda, H Holtmann. 1997. TNF receptors--how they function and interact.. https://pubmed.ncbi.nlm.nih.gov/9522999/

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