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PubMed · 9523178

Antisense oligonucleotides.

N Kashihara·Y Maeshima·H Makino
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Abstract

Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense oligonucleotides. This technique was originally used to elucidate the function of a target gene, but may also have therapeutic applications, provided it is designed carefully and properly.

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AnimalsGenetic TherapyHumansKidney DiseasesOligonucleotidesOligonucleotides, AntisenseRNA, MessengerRibonuclease HJournal ArticleReview

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N Kashihara, Y Maeshima, H Makino. Antisense oligonucleotides.. https://doi.org/10.1159/000020509

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