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PubMed · 9525681

Adenovirus internalization and infection require dynamin.

K Wang·S Huang·A Kapoor-Munshi·G Nemerow
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Abstract

The cell receptors that facilitate adenovirus internalization into cells have been identified; however, the infectious pathway of virus entry has not been established. Adenovirus entry and infection were examined in HeLa cells lacking or overexpressing mutant dynamin, a protein that specifically regulates clathrin-mediated endocytosis. Expression of mutant dynamin significantly reduced adenovirus internalization and gene delivery, indicating a functional requirement for this molecule. These findings are consistent with virus entry via the clathrin-coated pit pathway.

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Adenoviruses, HumanDynaminsGTP PhosphohydrolasesGenes, ReporterGreen Fluorescent ProteinsHeLa CellsHumansLuminescent ProteinsMutagenesisTetracyclineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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K Wang, S Huang, A Kapoor-Munshi, G Nemerow. 1998. Adenovirus internalization and infection require dynamin.. https://doi.org/10.1128/jvi.72.4.3455-3458.1998

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