Endothelin-converting enzyme: its functional aspect.

O A Gomazkov

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PubMed · 9526103

Endothelin-converting enzyme: its functional aspect.

O A Gomazkov

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Abstract

The system of endothelin peptides and their structure, biological activity, and role in physiological and pathological processes are reviewed with emphasis on endothelin-converting enzyme (ECE), which catalyzes the terminal processing of endothelin. Molecular specificity, structure, isoforms, physicochemical characteristics, substrate preference, and tissue localization characterize this enzyme as a novel and highly important metalloendopeptidase. The role of ECE in pathological processes and data on inhibitors of the enzyme which can have medical implication are summarized.

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Amino Acid Sequence Animals Aspartic Acid Endopeptidases Endothelin-1 Endothelin-Converting Enzymes Endothelins Humans Isoenzymes Metalloendopeptidases Models, Chemical Molecular Sequence Data Protein Conformation Protein Precursors Journal Article Review

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O A Gomazkov. 1998. Endothelin-converting enzyme: its functional aspect.. https://pubmed.ncbi.nlm.nih.gov/9526103/

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