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PubMed · 9529622

Ouabain-like factor.

A Goto·K Yamada
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Abstract

Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced hypertension. Furthermore, blocking the action of ouabain-like factor with digibind or a novel anti-ouabain agent lowers blood pressure in several models of hypertension. Several important questions remain, however, before it can be concluded that ouabain-like factor is indeed involved in the regulation of sodium homeostasis and blood pressure.

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AnimalsBiological FactorsBlood PressureCardenolidesDigoxinEnzyme InhibitorsHumansHypertensionNatriuresisSaponinsSodium-Potassium-Exchanging ATPaseJournal ArticleReview

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BibTeXRIS

A Goto, K Yamada. 1998. Ouabain-like factor.. https://doi.org/10.1097/00041552-199803000-00008

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