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Sustained decrease of peripheral lymphocytes after allogeneic blood stem cell aphereses.

J Novotny·J Kadar·B Hertenstein·D Schröder·D Petersen·L Arseniev·W Stangel·A Ganser
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Abstract

48 healthy donors underwent peripheral blood stem cell (PBSC) apheresis for allogeneic transplantation beginning on day 4 of G-CSF (2 x 5 microg/kg) mobilization. In one to four (median two) large-volume mononuclear cell aphereses, a median of 55.9 x 10(9) of lymphocytes (range 21.0-109.2 x 10[9]) were collected, an amount comparable to lymphocyte numbers removed by therapeutic lymphaphereses in autoimmune diseases. Mean peripheral lymphocyte counts decreased from premobilization values of 2.31 x 10(9)/l to 1.31 x 10(9)/l at a median of 34 d (1 month) and 1.53 x 10(9)/l at a median of 327 d (11 months). The decrease in peripheral lymphocyte counts was significantly correlated with the number of lymphocytes removed and the number of aphereses. Neutrophil and platelet counts returned to normal values after 1 month whereas monocyte counts and haemoglobin concentrations were significantly decreased at 1 month but not at 11 months.

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FemaleHematopoietic Stem Cell TransplantationHumansLeukapheresisLeukocyte CountLymphopeniaMaleNeutrophilsPlatelet CountRetrospective StudiesJournal Article

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J Novotny, J Kadar, B Hertenstein, D Schröder, D Petersen, L Arseniev, W Stangel, A Ganser. 1998. Sustained decrease of peripheral lymphocytes after allogeneic blood stem cell aphereses.. https://doi.org/10.1046/j.1365-2141.1998.00629.x

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