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PubMed · 9538410

[Epstein-Barr virus and cellular immortalization].

V Marechal·A Dehée·J C Nicolas
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Abstract

Epstein-Barr virus has been associated to several forms of neoplasia including Burkitt's lymphoma, B lymphomas in immuno-compromised patients and undifferentiated nasopharyngeal carcinoma. Immunodepression, genetic and/or environmental factors and the expression of several viral genes (latent genes mainly) may contribute to these pathologies. In vitro, several latent proteins (EBNA 1, 2, 3A, 3C, 5 et LMP-1) directly or indirectly contribute to the initiation and maintenance of the transformation process. The role of these proteins is discussed in the present article.

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AnimalsCell Transformation, NeoplasticCell Transformation, ViralGenes, ViralHerpesvirus 4, HumanHumansVirus LatencyEnglish AbstractJournal ArticleReview

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V Marechal, A Dehée, J C Nicolas. 1997. [Epstein-Barr virus and cellular immortalization].. https://pubmed.ncbi.nlm.nih.gov/9538410/

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