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Ischaemic preconditioning: present position and future directions.

D M Yellon·G F Baxter·D Garcia-Dorado·G Heusch·M S Sumeray
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Abstract

Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective adaptation of the myocyte has also been observed in other cell types. The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion injury and the regulatory mechanisms underlying cellular metabolism. We feel it is timely to assess the current position in this field and provide a critical appraisal to facilitate future research.

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AnimalsHumansIschemic PreconditioningIschemic Preconditioning, MyocardialMyocardial IschemiaMyocardial Reperfusion InjuryMyocardiumPotassium ChannelsProtein Kinase CReceptors, Purinergic P1ResearchSignal TransductionJournal ArticleReview

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D M Yellon, G F Baxter, D Garcia-Dorado, G Heusch, M S Sumeray. 1998. Ischaemic preconditioning: present position and future directions.. https://doi.org/10.1016/s0008-6363(97)00214-9

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