PubMed · 954183
A simple method for "reference range" estimation from routine laboratory data.
Abstract
A simplified method is presented to estimate reference ranges from hospital laboratory data. It is based on a combination of graphical estimation of relative sizes of normal and abnormal populations and the "mode-center" concept in which the mode of the total population centers on the 50% cumulative frequency of the normal population. This method can be applied to determine reference ranges even though the data source contains abnormally high and/or low values. The reference ranges obtained for BUN and calcium from in-patient and out-patient sources by this method were found to be similar to those reported for "healthy" subjects.
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S Y Chu, P Cheung, V E Turkington. 1976. A simple method for "reference range" estimation from routine laboratory data.. https://doi.org/10.1016/s0009-9120(76)80057-4
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